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Footnotes:

1. Mittag, T. W., Guo, W. B. & Kobayashi, K. Bicarbonate-activated adenylyl cyclase in fluid-transporting tissues. Am J Physiol 264, F1060-1064 (1993).

2. Lee, Y.S., et al. Regulation of intraocular pressure by bicarbonate regulated soluble adenylyl cyclase. Submitted.

3. Strazzabosco, M. et al. Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. Hepatology 50, 244-252 (2009).

4. Hallows, K. R. et al. Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem 284, 5774-5783 (2009).

5. Sun, X. C. et al. HCO3--dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium. Am J Physiol Cell Physiol 284, C1114-1122 (2003).

6. Sun, X. C., Cui, M. & Bonanno, J. A. [HCO3-]-regulated expression and activity of soluble adenylyl cyclase in corneal endothelial and Calu-3 cells. BMC Physiol 4, 8 (2004).

7. Wang, Y. et al. Regulation of CFTR channels by HCO3--sensitive soluble adenylyl cyclase in human airway epithelial cells. Am J Physiol Cell Physiol 289, C1145-1151 (2005).

8. Baudouin-Legros, M. et al. Control of basal CFTR gene expression by bicarbonate-sensitive adenylyl cyclase in human pulmonary cells. Cell Physiol Biochem 21, 075-086 (2008).

9. Halm, S. T., Zhang, J. & Halm, D. R. β-adrenergic activation of electrogenic K+ and Cl- secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways. Am J Physiol Gastrointest Liver Physiol 299, 81-95 (2010).