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Footnotes:

1. Esposito, G. et al. Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A 101, 2993-2998 (2004).

2. Hess, K. C. et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell 9, 249-259 (2005).

3. Farrell, J.*, Ramos, L.*, Tresguerres, M., Kamenetsky, M., Levin, L.R., and Buck, J. (2008). Somatic 'Soluble' adenylyl cyclase isoforms are unaffected in Sacytm1Lex/Sacytm1Lex 'Knockout' mice. PLoS ONE 3(9) e3251.

4. Schmid, A. et al. Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol 130, 99-109 (2007).

5. Schmid, A. et al. Decreased soluble adenylyl cyclase activity in cystic fibrosis Is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation. J Biol Chem 285, 29998-30007 (2010).

6. Acin-Perez, R. et al. Cyclic AMP Produced inside Mitochondria Regulates Oxidative Phosphorylation. Cell Metabolism 9, 265-276 (2009a).

7. Acin-Perez, R. et al. Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects. Embo Molecular Medicine 1, 392-406 (2009b).

8. Acin-Perez, R. et al.. Protein Phosphorylation and Prevention of Cytochrome Oxidase Inhibition by ATP: Coupled Mechanisms of Energy Metabolism Regulation Cell Metabolism 13, 712 - 719(2011).

9. Mittag, T. W., Guo, W. B. & Kobayashi, K. Bicarbonate-activated adenylyl cyclase in fluid-transporting tissues. Am J Physiol 264, F1060-1064 (1993).

10. Lee, Y.S., et al. Regulation of intraocular pressure by bicarbonate regulated soluble adenylyl cyclase. Submitted.

11. Strazzabosco, M. et al. Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. Hepatology 50, 244-252 (2009).

12. Geng, W. et al. Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase. J Cell Physiol 220, 332-340 (2009).